Adding a certain compound to certain chemical reactions, such as: 552330-86-6, name is 5-Bromoisoindolin-1-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 552330-86-6, name: 5-Bromoisoindolin-1-one
(i) (S)-tert-Buty l-(l-amino-3-(4-(l-(difluoromethyl)-6-oxo-l,6-dihydropyridin-3- yl)phenyl)-l-oxopropan-2-ylcarbamoyl)cyclohexylcarbamatePotassium carbonate (178 mg) in water (5 mL) was added to (S)-tert-butyl l-(l-cyano-2-(4- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl)ethylcarbamoyl)cyclohexylcarbamate (Example 23 step (i), 300 mg), 5-bromoisoindolin-l-one (141 mg) and 1,1 bis(di-tert- butylphosphino)ferrocene palladium dichloride (12 mg) in degassed acetonitrile (15 mL) at 20C under an atmosphere of nitrogen. The resulting solution was stirred at 90C for 4h. The reaction mixture was concentrated to dryness and the residue purified by chromatography on silica eluting with ethyl acetate to afford the sub-titled compound (180 mg) as a colourless solid.
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Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; FORD, Rhonan; KINCHIN, Elizabeth; MATHER, Andrew; METE, Antonio; MILLICHIP, Ian; STANIER, Andrew Geoffrey; WO2011/154677; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem