Electric Literature of 2307-00-8, These common heterocyclic compound, 2307-00-8, name is 5-Amino-2-methylisoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 20: 2-METHYL-5 -IY2-OXO-1 -PHENYL- 1.2-DIHYDRO-3 H-INDOL-3- YLIDENE)AMINO1-2H-ISOINDOLE- 1 ,3(2H)-DIONE: A mixture of 1-phenylisatin (50 mg, 0.22 mmol) and 4-amino-N-methylpthalimide (40 mg, 0.22 mmol) was heated neat at 215 0C for 2 h. The crude material was purified by preparative TLC using a mixture of 3:7 ethyl acetate and hexane as the eluent, giving the desired product as a yellow solid (8 mg, 0.02 mmol, 10 %). 1H NMR (400 MHz): delta 7.88 (d, J = 7.8, IH), 7.83 – 7.80 (m, IH), 7.51 (t, J = 7.5, IH), 7.47 – 7.18 (m, 6H), 7.02 (t, J = 8.0, IH), 6.91 – 6.79 (m, 2H), 6.58 (d, J = 7.5, IH), 3.22 (s, 3H); ESI-MS m/z found 382 (MH+).
The synthetic route of 2307-00-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HELICON THERAPEUTICS, INC.; WO2008/2946; (2008); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem