Some common heterocyclic compound, 32692-19-6, name is 5-Nitroindoline, molecular formula is C8H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H8N2O2
Reference Example 49 7-bromo-5-nitro-1H-indoline 5-nitro-1H-indoline (2.0 g) was dissolved in acetic acid (15.0 mL), bromine (1.0 mL) was added, and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into ice water, and this was neutralized with a 1 mol/L aqueous sodium hydroxide solution. The produced crystal was filtered and washed with water, and the resulting crystal was then dried under reduced pressure to obtain the title compound (3.3 g). 1H NMR (CDCl3) delta (ppm): 3.27(2H,t), 3.86(2H,t), 7.90(1H,s), 8.19(1H,s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 32692-19-6, its application will become more common.
Reference:
Patent; Sanwa Kagaku Kenkyusho Co., Ltd; EP2036887; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem