Application of 897957-06-1,Some common heterocyclic compound, 897957-06-1, name is 6-Bromo-1-methylindolin-2-one, molecular formula is C9H8BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 3: Synthesis of Intermediate R12To 1-5.2 (32.0 g, 142 mmol) in anhydrous dioxane (400 mL) is added Ri 1 (54.4 g, 241 mmol) andpotassium acetate (41.6 g, 424 mmol). The mixture is purged with Argon, [1, 1?-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) as a complex with dichloromethane (11.2 g, 14 mmol) is added and the mixture is heated to 90 C for 2 h. The reaction mixture is diluted with ethyl acetate and water, the organic layer is washed with water, dried over Mg504 and concentrated. The residue is purified via flash chromatography (cyclohexane / EA = 70:30). Yield72%, m/z 274 [M+H]+, rt 0.67 mi LC-MS Method VOil SOl.
The synthetic route of 897957-06-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ANDERSKEWITZ, Ralf; GRAUERT, Matthias; GRUNDL, Marc; OOST, Thorsten; PAUTSCH, Alexander; PETERS, Stefan; WO2014/140091; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem