Introduction of a new synthetic route about 3-(1,3-Dioxoisoindolin-2-yl)propanal

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(1,3-Dioxoisoindolin-2-yl)propanal, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2436-29-5, Safety of 3-(1,3-Dioxoisoindolin-2-yl)propanal

Example 12d (0.06 g, 0.135 mmol) and 3-(l ,3-dioxoEomdoliiv2-yl)propa-ial (0082 g, 0.406 mmol) were combined in tetrahydiiofuran (1 .353 mL) under nitto gen and treated drop-wise with 1 M utanium(IV) chloride in toluene (0.406 mL, 0.406 mmol) . The reaction mixture was stirred lor 18 hours at 60 * C, cooled to artfc ient temperature, and partitioned b etwee II ethyl acetate and water. The organic layer was was lied with s aturated aqueous sodium cluotide, dried over arfoydrous sodium sulfate, filtered and concentrated. Irification b y revers e phase HPLC (C IS, C CNAvater (0.1 “A TFA), 0- 100 % gradient) provided the title compound. (0.018 g, 21 ). NMR (500 MHz, DMS O-^ 6 11 94 (d, J = 2.14 Hz, 1H1 7.88 (d, J = 1 53 Hz, 1H), 7.80 – 786 (m, 4H), 7.72 (s, 1H), 7.31 (d, J = 2.75 Hz, IK), 728 (dd, J = 3D9, 1.98 Hz, 1 H), 7.02 – 7.10 (m, 2H), 6.77 – 6.83 (m, 1H), 6.65 – 6.72 (m, 1 5.06 – 5.1 1 (m. 1H), 4.40 – 4.57 (m, 2H), 3.70 – 3.79 (m, 1H), 3 65 ( , 3H), 354 – 3.63 (m, lH), 2.95 (s, 3H), 1 91 – 2.07 (m, 1 1.62 (dd, J = 13.12, 5.19 Hz, 1H). MS (ES I+) mfe 629 (M+H) 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(1,3-Dioxoisoindolin-2-yl)propanal, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; FIDANZE, Steven D.; LIU, Dachun; MANTEI, Robert A.; MCDANIEL, Keith F.; PRATT, John; SHEPPARD, George S.; WANG, Le; BOGDAN, Andrew; HOLMS, James H.; DIETRICH, Justin D.; MARJANOVIC, Jasmina; HASVOLD, Lisa A.; DAI, Yujia; WO2014/139324; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem