Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 875003-43-3, name is 7-Fluoro-1-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 7-Fluoro-1-methylindoline-2,3-dione
Add beta-bromocycloalkenyl formaldehyde (131.2 mg, 0.75 mmol), N-methyl-7-fluoroisatin (89.6 mg, 0.5 mmol), thiazole salt (18.6 mg, 0.05 mmol) to a dry Schlenk tube. , Cesium carbonate (162.9 mg, 0.5 mmol), dioxane (5 mL), and heated under reflux for 12 hours. After the reaction was completed, the reaction solution was cooled and the solvent was removed by rotary evaporation. The product was separated by silica gel column chromatography (petroleum ether / ethyl acetate = 4/1) to obtain 100.0 mg of the product as a pale yellow solid with a yield of 73%.
The synthetic route of 875003-43-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wuhan Institute of Technology; Wang Gang; Wu Jiang; Cheng Xing; He Zhaolin; Yuan Xiangfu; Xi Jiangbo; (9 pag.)CN110698490; (2020); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem