Related Products of 19155-24-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19155-24-9 as follows.
Preparation of l-(3-chloropropyl)-3,3-dimethylindolin-2-one; [0231] A solution of 3,3-dimethylindolin-2-one (1.843 g, 11.43 mmol, 1 equiv) in N,N- dimethylformamide was cooled to 0¡ãC. Sodium hydride (60percent dispersion) (503 mg, 12.58 mmol, 1.1 equiv) was slowly added and the reaction was stirred as such until all bubbling had stopped. 1 – bromo-3-chloropropane (3.37 ml, 34.3 mmol, 3 equiv) was added to the reaction mixture in one portion. The reaction was allowed to warm to ambient temperature and stirred as such for 16 h. The crude mixture was partitioned between ethyl acetate and water. The organic layer was dried over MgSO i, filtered, concentrated, and the residue was purified using the Biotage flash chromatography system (SNAP 50 g cartridge, R/= 0.5, gradient – 5percent>-30percent> ethyl acetate in hexanes) to afford the title compound as a light orange oil (2.38 g, 87percent); ‘i/NMR (400 MHz, DMSO-i/6): delta 1.26 (s, 6H); 1.98-2.14 (m, 2H); 3.65 (t, 2H, J= 6 and 6.8 Hz); 3.77-3.81 (m, 2H); 7.02-7.07 (m, 2H); 7.24-7.28 (m, 1H); 7.33-7.35 (m, 1H); MS for C13H16C1N0 m/z 237.99 (M+H)+.
According to the analysis of related databases, 19155-24-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ALTOS THERAPEUTICS, LLC; LUEHR, Gary, W.; SUNDARAM, Arathi; JAISHANKAR, Priyadarshini; PAYNE, Philip, W.; DRUZGALA, Pascal; WO2011/160084; (2011); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem