Related Products of 239463-85-5,Some common heterocyclic compound, 239463-85-5, name is (R)-3-(5-(2-Aminopropyl)-7-cyanoindolin-1-yl)propyl benzoate (2R,3R)-2,3-dihydroxysuccinate, molecular formula is C26H31N3O8, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a slurry of SI-I (769 g, 1.50 mol) as the tartrate salt (e.e. 98.3%) in dichloromethane (2 L) was added dropwise an aqueous solution of sodium hydroxide (5 N, 126 g, 3.15 mol) at 10 C, all in a round bottom flask (5 L). The reaction mixture was stirred until the pH was 11. The organic layer was separated and the aqueous layer was extracted with dichloromethane twice (500 ml 2). The combined organic layer was washed with water to neutrality, dried over sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the SI-II (531 g, 97.5%, HPLC 98.2%) as a light yellow oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (R)-3-(5-(2-Aminopropyl)-7-cyanoindolin-1-yl)propyl benzoate (2R,3R)-2,3-dihydroxysuccinate, its application will become more common.
Reference:
Article; Liu, Hui; Lv, Fei; Liu, Yuan; Organic Preparations and Procedures International; vol. 51; 3; (2019); p. 287 – 293;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem