Application of 1504-06-9,Some common heterocyclic compound, 1504-06-9, name is 3-Methyloxindole, molecular formula is C9H9NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In the Schlenk bottle to point pen 1 b indicated by the 2 – indolone derivatives (29.4 mg, 0.2 mmol), butyl alcohol peroxide (t – BuOOH, 43.2 mg, 0 . 48 mmol), then adding the solvent water (2 ml), then the reactor in air atmosphere, 80 C stirring under the conditions of the reaction, TLC monitoring the reaction by the disappearance of the process until the raw material (the reaction time is 24 hours), after the reaction, the reaction solution is extracted with ethyl acetate three times, the organic phase dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent, the residue by column chromatography (elution solvent: ethyl acetate/hexane) to obtain the target product I – 2. (86% Yield);
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Methyloxindole, its application will become more common.
Reference:
Patent; Ningbo University; Song Sizhe; Wei Wenting; Bao Wenhui; Meng Yanan; Meng Xiaoxiao; (10 pag.)CN109776387; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem