Related Products of 2058-72-2,Some common heterocyclic compound, 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, molecular formula is C9H6BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A septum-capped vial with a stirring bar was charged with the corresponding isatin(0.1 mmol), ester (0.2 mmol, 2.0 equiv.), catalyst and solvent (1 mL). The reactionmixture was conducted in setting temperature and monitored by TLC. The resultingreaction mixture was vapored in vacuum and the residue was purified by columnchromatography (Hexane/EtOAc = 8/1 to 4/1). The desired products were obtained ascolorless oil or white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-1-methylindoline-2,3-dione, its application will become more common.
Reference:
Article; Zhang, Xianhui; Zhou, Li; Mahmood, Qaiser; Zhao, Mengmeng; Wang, Xiaowu; Wang, Qinggang; Synlett; vol. 30; 5; (2019); p. 573 – 576;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem