480-91-1, name is Isoindolin-1-one, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Isoindolin-1-one
Isoindolin-1-one 21 (250mg, 1.85mmol) was dissolved in acetonitrile (9mL) and cesium carbonate (2.40g, 7.39mmol) was added followed by propargyl bromide (308muL, 2.77mmol). The reaction mixture was stirred at reflux (2h). The reaction mixture was then dissolved in CH2Cl2 (10mL) and washed with water (3¡Á15mL). The organic layer was dried (Na2SO4), filtered and concentrated under reduced pressure. Gravity-column chromatography of the residual oil (hexane/ethyl/acetate, 2:1) gave 27 as a yellow solid (205mg, 65%): mp 79-81C; Rf 0.66 (ethyl acetate); 1H NMR (400MHz, CDCl3) delta 7.82 (dJ=8.0Hz, 1H), 7.52 (dd J=8.0, 7.2Hz, 1H) 7.41-7.45 (m, 2H), 4.47 (s, 2H), 4.24 (s, 2H), 2.28 (s, 1H). 13C NMR (100MHz, CDCl3) delta 167.9, 141.2, 132.1, 131.6, 128.1, 123.8, 122.8, 78.1, 72.5, 49.1, 31.7. IR (neat) 3290, 3243, 2118, 1701cm-1; HRMS (ESI-TOF) m/z [M+H]+; calculated for C11H10NO 172.0762, Found: 172.0857.
The synthetic route of 480-91-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ronnebaum, Jarrid M.; Luzzio, Frederick A.; Tetrahedron; vol. 72; 40; (2016); p. 6136 – 6141;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem