Reference of 20876-36-2,Some common heterocyclic compound, 20876-36-2, name is 5-Aminoindolin-2-one, molecular formula is C8H8N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
153 mg (0.490 mmol) (5-Bromo-2-chloro-pyrimidin-4-yl)-phenethyl-amine was taken into 0.5 mL 1,4 dioxane with 0.14 mL (1.00 mmol) diisopropylethylamine and 80 mg (0.539 MMOL) 5-amino-1, 3-DIHYDRO-INDOL-2-ONE. The reaction was allowed to heat to 110 C for sixteen hours. The resulting brown glass was taken into 92.3 : 7: 0.7 CHCI3 : CH30H: NH40H and washed with 1 N sodium hydroxide. The organic layer was dried over magnesium sulfate and evaporated directly onto silica gel. This adsorbed compound was purified via column chromatography (97.8 : 2: 0.2 CHCI3 : CH30H: NH40H) over silica to isolate the major product.the title compound was isolated as a white solid. c2ohigbrn50 : ms: 424.2/426. 2 (mh+) ;’h nmr (d6-dmso) 10.20 (s, 1 h), 9.01 (s, 1 h), 7.93 (s, 1 h), 7.52 (s, 1 h), 7.44 (d, j = 8.4 hz, 1 h), 7.28-7. 16 (m, 5 h), 6.97 (m, 1 h), 6.65 (d, j=8. 3hz, 1 h), 3.56 (m, 2 h), 3.31 (s, 2 h), 2.82 (t, j=7. 9hz, 2h) ppm.
The synthetic route of 20876-36-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/56786; (2004); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem