Related Products of 20870-79-5, A common heterocyclic compound, 20870-79-5, name is 5-Nitroindolin-2-one, molecular formula is C8H6N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A reaction mixture of 5-nitroindolin-2-one (356 mg, 2 mmol),the appropriate aldehyde (2.4 mmol, 1.2 equiv.) and piperidine(21 muL, 0.2 mmol, 0.1 equiv) in DMF (5 mL) was stirred at 80 C for4 h. The solventwas removed under reduced pressure, the resultingresidue was suspended in ethyl ether (15 mL) and filtered, tofurnish the target compound used without any further purificationfor the next reaction.
The synthetic route of 20870-79-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Romagnoli, Romeo; Baraldi, Pier Giovanni; Prencipe, Filippo; Oliva, Paola; Baraldi, Stefania; Salvador, Maria Kimatrai; Lopez-Cara, Luisa Carlota; Bortolozzi, Roberta; Mattiuzzo, Elena; Basso, Giuseppe; Viola, Giampietro; European Journal of Medicinal Chemistry; vol. 134; (2017); p. 258 – 270;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem