Related Products of 7699-18-5,Some common heterocyclic compound, 7699-18-5, name is 5-Methoxyindolin-2-one, molecular formula is C9H9NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of 2-oxindole (3.76mmol) in dry THF (8 mL) was added BuLi (1.63 M, 7.52 mmol) at -78 C followedby N,N,N,N-tetramethylethylenediamine (7.52 mmol). After stirring themixture for 1 h at the same temperature, 4-(2-iodoethyl)-N,N-dimethylaniline(4.51 mmol) dissolved in THF (8 mL) was added dropwise to thesolution. Then, the solution was allowed to warm to ambient temperature, andthe stirring was continued for further 2 h. The reaction mixture was pouredinto saturated ammonium chloride solution and the product was extracted withethyl acetate. The organic layer was dried over anhydrous sodium sulfate,filtered, and concentrated under reduced pressure. The residual was purified bysilica gel column chromatography (hexane/ethyl acetate/acetone = 5/1/1) toafford 2 (74%) as a pale pink solid.
The synthetic route of 7699-18-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Furuta, Kyoji; Kawai, Yu; Mizuno, Yosuke; Hattori, Yurika; Koyama, Hiroko; Hirata, Yoko; Bioorganic and Medicinal Chemistry Letters; vol. 27; 18; (2017); p. 4457 – 4461;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem