Electric Literature of 52351-75-4, These common heterocyclic compound, 52351-75-4, name is 6-Methoxyindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 6-methoxyisatin(0.18g, 0.001 mol) in Anhyd. ethanol (2m1) and thiosemicarbazide(0.1g, 0.0011 mol) in a mixture of water (2 ml)andglacialacetic acid (0.5 ml) was irradiated under microwave irradiation at560W for 5-minutes. A yellowcoloured solid formed during irradiation. The solid was filtered, washed well with water andcrystallized from ethanol-DMF furnishing yellow crystals.yield 0.247g (95%), m.p. 265C.[Found : N, 22.68, S,12.62. C1DH,0N402S requires N, 22.40; S, 12.80%];IR: 825, 860 (1, 2, 4-trisubstituted benzene ring), 1115 (C=S), 1125 & 1370 (C-O-Cstretching), 1620 (C=N), 1700 (C=O), 3200, 3280, 3400 (NH, NH2).
The synthetic route of 52351-75-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Singh, Ravinder; Oriental Journal of Chemistry; vol. 30; 1; (2014); p. 319 – 323;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem