Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3676-85-5, name is 5-Aminoisoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 5-Aminoisoindoline-1,3-dione
Example 86 N-(1,3-Dioxo-2,3-dihydro-1H-5-isoindolyl)-N’-(2-nitrobenzyl)urea Diphenylphosphoryl azide (165 mg, 0.60 mmol, 1.2 eq) and triethylamine (61 mg, 0.60 mmol, 1.2 eq) were added to a solution of 2-nitrophenylacetic acid (90 mg, 0.50 mmol) in toluene, and the mixture was stirred at 110C for 60 min. Thereafter, 4-aminophthalimide (81 mg, 0.50 mmol, 1.0 eq) and a minor amount of DMF were added thereto, and the mixture was stirred at 110C for 2 hr. After the completion of the reaction, water and ethyl acetate were added thereto, and the precipitated crystal was collected by filtration, was washed with ethyl acetate, and was further washed with a chloroform/methanol solution to give the title compound as a crystal (11 mg, 6.5%). MS m/z: 340 1H-NMR delta: 4.61 (2H, d, J = 5.37 Hz), 7.00 (1H, t, J = 5.73 Hz), 7.53 – 7.70 (4H, m), 7.76 (1H, t, J = 7.44 Hz), 8.00 (1H, s), 8.06 (1H, d, J = 7.44 Hz), 9.48 (1H, s), 11.09 (1H, s)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1256574; (2002); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem