56341-37-8, name is 6-Chlorooxindole, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 56341-37-8
General procedure: Synthesis of 6-chlorooxindole derivatives was carried out by refluxing 6-chlorooxindole with different aromatic aldehydes in ethanol in the presence of a catalytic amount of piperidine. The reaction mixture was refluxed for 3 h. After completion of reactionas determined by TLC analysis, the contents were cooled and concentrated at reduced pressure to afford solid 3-oxindole derivatives. The product was washed with equal volumes of a mixture of hexane-ethyl acetate (25 mL) and dried to afford compounds 1-25.20 1H NMR, EI spectroscopy and CHN analysis were used for the determination of their structures. 4.1.18 (E)-3-(3-Methoxybenzylidene)-6-chloroindolin-2-one (18) Yield: 0.24 g (84%); 1H NMR (500 MHz, DMSO-d6): delta 10.75 (s, 1H, -NH), 7.63 (s, 1H, =CH), 7.52 (d, 1H, J4,5 = 8.0 Hz, H-4), 7.43 (t, 1H, J5′(4′,6′) = 8.0, H-5′), 7.24(t, 1H, J4′(3′,5′) = 8.0, H-4′), 7.23 (d, 1H, J6′,5′ = 8.0 Hz, H-6′), 7.04 (d, 1H, J3′,4′ = 8.0 Hz, H-3′), 6.93 (dd, 1H, J5,7 = 1.5, J5,4 = 8.0 Hz, H-5), 6.88 (d, 1H, J7,5 = 1.5 Hz, H-7), 3.79 (s, 3H, -OMe); MS: m/z (rel. abund.%) 285 (M+, 100), 178 (59), 152 (32), 63 (56); Anal. Calcd for C16H12ClNO2 (285.72): C, 67.26; H, 4.23; Cl, 12.41; N, 4.90; O, 11.20; Found: C, 67.28; H, 4.22; N, 4.88.
The synthetic route of 56341-37-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Khan, Momin; Yousaf, Muhammad; Wadood, Abdul; Junaid, Muhammad; Ashraf, Muhammad; Alam, Umber; Ali, Muhammad; Arshad, Muhammad; Hussain, Zahid; Khan, Khalid Mohammed; Bioorganic and Medicinal Chemistry; vol. 22; 13; (2014); p. 3441 – 3448;,
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