In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7147-90-2, name is 5-Chloroisoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 5-Chloroisoindoline-1,3-dione
7a: A mixture of concentrated sulfuric acid (24 mL) and fuming nitric acid (1.5 mL) was added dropwise to 4-chloro-phthalimide 6 (4.90 g, 27.0 mmol). The reaction mixture was heated at 80 C for 0.5 h. After cooling to r.t. the dark red solution was poured into ice. The resulted yellow precipitate was collected by filtration, washed with water, dried in vacuum affording a pale yellow solid 7a (3.52 g, 58% yield). 1H NMR (DMSO-d6): delta (ppm) 11.87 (s, 1H, CONHCO), 8.51 (s, 1H, Ar-H), 8.27 (s, 1H, Ar-H). 13C NMR (DMSO-d6): delta (ppm) 166.66, 166.62, 151.28, 135.96, 132.43, 130.30, 126.03, 119.62.
The synthetic route of 7147-90-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Song, Xiaoyu; Zhao, Jing; Zhang, Wandong; Chen, Long; Chinese Chemical Letters; (2018); p. 331 – 335;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem