Electric Literature of 446292-08-6,Some common heterocyclic compound, 446292-08-6, name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, molecular formula is C22H19N3O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) 40 g of the compound of Formula 4 and 200 mL of ethanol are mixed at room temperature.Stir at room temperature. The temperature was raised to 40 C., a 200 mL aqueous solution of 12.0 potassium sulfide was dropped at 60 C. or lower, and the reaction was carried out at 40 to 40 C. for 4 to 5 hours. After 50 C, vacuum concentration to 150 ~ 200mL, 0 ~ 10 C stirring for 2 hours,Filtration and drying gave 26.3 g of a dry product of the compound of formula 3 in a yield of 95%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, its application will become more common.
Reference:
Patent; Zhejiang Mei Nuohua Pharmaceutical Chemical Co., Ltd.; Liu Xiong; Huang Xiangliang; Cao Qian; Chen Weiren; Yao Chengzhi; Zeng Wei; (9 pag.)CN107936006; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem