Month: April 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 868066-91-5, name is 5-Bromo-2-methylisoindolin-1-one, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 5-Bromo-2-methylisoindolin-1-one

To a mixed solution of compound 1b (5 g, 22 mmol), bisboronic acid pinacol (8.5 g, 33 mmol) and KOAc (3.2g, 33 mmol) in 1,4 dioxane (50 ml) was added Pd(dppf)2Cl2 (1g), and flushed with nitrogen. The reaction flask wassealed and the reaction was stirred overnight at 85°C. After cooling to room temperature, an aqueous Na2CO3 solution(2.5M, 10ml), Pd(dppf)2Cl2 (1g) and 2,5-dibromo-3-nitropyridine (9 g, 33 mmol) were added. After flushed with nitrogenfor 10 minutes, the reaction flask was sealed and the mixture was stirred overnight at 85°C. The reaction was pouredinto water and extracted with ethyl acetate. The organic phase mixture was dried over Na2SO4, dried by suction andpurified by silica gel column chromatography (PE:EA=10:1 to 1:1) to provide compound 1c as a yellow solid.HNMR(CDCl3),9.0(s,1H),8.4(s,1H),8.0(d,1H),7.6-7.7(m,2H),4.5(s,2H),3.3(s,3H).MS(ESI)m/z :347.9(M+H)+.

According to the analysis of related databases, 868066-91-5, the application of this compound in the production field has become more and more popular.

Synthetic Route of 84575-27-9, These common heterocyclic compound, 84575-27-9, name is 7-Methoxyindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In another example, N-methyl-7-methoxyindoline-2,3-dione (S5) is prepared according to Scheme 1h: To a solution of 7-methoxyindoline-2,3-dione (SM5) (16.7 g, 94.3 mmol, 1.0 equiv) and N,N-dimethylformamide (205 mL) was added sodium hydride (4.41 g, 104 mmol, 60% dispersion in mineral oil, 1.1 equiv) at rt. After 10 min, iodomethane (6.45 mL, 104 mmol, 1.1 equiv) was added, and the reaction mixture was maintained at rt for 4 hr. The reaction mixture was then poured into ice water (800 mL) and the resulting dark red precipitate was collected by vacuum filtration. The solid was washed with water (2*300 mL), redissolved in dichloromethane (700 mL), dried over MgSO4, and concentrated to provide isatin S5 (16.1 g, 90%) as a dark red solid: 1H NMR (500 MHz, CDCl3) delta 7.22 (dd, J=7.4, 1.1, 1H), 7.16 (dd, J=8.3, 1.0, 1H), 7.04 (dd, J=8.3, 7.4, 1H), 3.90 (s, 3H), 3.50 (s, 3H), 0.95 (s, 3H); HRMS-ESI (m/z) [M+Na]+ calcd for C10H9NO3Na, 214.0480; found, 214.0482.

Statistics shows that 7-Methoxyindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 84575-27-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 954-81-4, name is N-(5-Bromopentyl)phthalimide, This compound has unique chemical properties. The synthetic route is as follows., Formula: C13H14BrNO2

General procedure: 4.2.1 Synthesis of ethyl 2-(3-(benzyloxy)-2-oxopyridin-1(2H)-yl)acetate (3a). To a solution of 2 (0.20 g, 0.99 mmol) in anhydrous DMF (3 mL) under N2 at 0 C was added NaH (0.044 g, 1.09 mmol). The mixture was warmed to rt and stirred for 30 min. After cooling back to 0 C, ethyl bromoacetate (0.12 mL, 1.09 mmol) was added and the mixture stirred at rt for 2 h. The reaction was quenched with saturated NH4Cl (10 mL) and the product extracted into ethyl acetate (3*30 mL). The combined organic extract was dried (Na2SO4) and the solvent removed in vacuo. Excess DMF was removed by Kugelrohr distillation. The crude product was purified by radial chromatography (hexane/ethyl acetate gradient) to give ester 3a (0.26 g, 93%) as a white solid.

According to the analysis of related databases, 954-81-4, the application of this compound in the production field has become more and more popular.

Reference of 317-20-4, These common heterocyclic compound, 317-20-4, name is 7-Fluoroisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of isatin (0.15 g, 1 mmol), 5,5-dimethylcyclohexane-dione (0.14 g, 1 mmol), barbituric (0.13 g, 1 mmol) in gluconic acid aqueous solution (3 ml) was stirred at 100 C. The reaction progress was monitored by thin-layer chromatography. After completion of the reaction, the reaction mixture was cooled to room temperature. Then, the precipitated product was filtered and washed with water. The crude product was crystallized from ethanol to give 4a.

The synthetic route of 317-20-4 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 264916-06-5, name is tert-Butyl 5-aminoisoindoline-2-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 264916-06-5

To 517 mg of P14 in 15 ml_ of THF at O0C was added 350 mg of 60% sodium hydride in mineral oil and the mixture stirred for 10 minutes. 570 mg of P15 was then added and the mixture warmed to room temperature. After three days the reaction mixture was quenched with water then extracted three times with ethyl acetate. The combined extracts were washed with brine, dried with magnesium sulfate, filtered and evaporated to dryness. Purification by flash chromatography yielded 450mg of 8. LCMS: 433.2 (MH+)

The synthetic route of tert-Butyl 5-aminoisoindoline-2-carboxylate has been constantly updated, and we look forward to future research findings.

Reference of 89-40-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89-40-7, name is 5-Nitroisoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.

General procedure: N-Methylation of phthalimide derivative M11 was obtained by nucleophilic displacement of iodide from alkyl iodide by deprotonated phthalimide. A mixture of appropriate phthalimide, iodoalkane, and potassium carbonate in DMF was stirred for 6-10 h at 70-110 C. After completion, the mixture was poured into an ice/water mixture. The aqueous phase was extracted with dichloromethane. The combined organic phase was washed with 0.1 HCl, brine and was dried over anhydrous sodium sulfate. The desired N-alkylated product was isolated using flash column chromatography.

The synthetic route of 5-Nitroisoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 141452-01-9 as follows. SDS of cas: 141452-01-9

Preparation of Intermediate 1-(4′-Trifluoromethyl-biphenyl-2-carbonyl)-2,3-dihydro-1H-indole-5-carboxylic acid methyl ester (I-5b) 4′-Trifluoromethyl-biphenyl-2-carboxylic acid (4.51 g, 16.9 mmol) and 2,3-dihydro-1H-indole-5-carboxylic acid methyl ester I-5a (3.0 g, 16.9 mmol) were dissolved in DCM (50 ml). PyBroP (8.4, 18 mmol) and hunig’s base (2.58 g, 20 mmol) were added to the above mixture the reaction mixture was stirred overnight. PyBroP (4 g) was added to the reaction mixture and the reaction mixture was stirred overnight.The reaction mixture was diluted with DCM (200 ML) and washed with a saturated solution of NaHCO3 (100 ml*3), HCl (1N, 150 ml*2).The organic layer was collected and dried (Na2SO4).The solvent was removed under reduced pressure and the residue was purified by flash chromatography to provide the desired product 3.5 g.

According to the analysis of related databases, 141452-01-9, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89-40-7, name is 5-Nitroisoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows., name: 5-Nitroisoindoline-1,3-dione

4-Nitrophthalimide (LOOGR) was taken into a beaker and dissolved using 300ML of dimethylformamide and 400ML of methanol. The solution was transferred into a 1L hydrogenation kettle and 20gr of wet Raney nickel catalyst was charged into the kettle. Hydrogenation was carried out initially at 20-40psi and 25-30C until the exothermic nature was over. Hydrogenation was further continued at 40-60psi pressure and 40-50C. After checking the completion of reaction by TLC, catalyst was removed by filtration and the solvents distilled off from the reaction mixture at 50-60C. The residue thus obtained was suspended in water (500ML) and filtered off to get a bright yellow crystalline compound of 4-aminophthalimide (78gr, 92.5%). Melting point: 294-5C.

According to the analysis of related databases, 89-40-7, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, This compound has unique chemical properties. The synthetic route is as follows., category: indolines-derivatives

EXAMPLE 12 (E)-1-(2,6-Dichlorophenyl)-3-(4-methyl-benzyli-dene)-1,3-dihydro-2H-indol-2-one 1-(2,6-Dichlorophenyl)-oxindole (22.24 g; 80 mmoles) and 4-methyl benzaldehyde (10.0 g; 84 mmoles) are dissolved in 250 ml of toluene, pyrrolidine (4.0 ml; 0.30 mole) is measured to the solution, and the mixture is warmed to reflux temperature. It is refluxed for 1 hour, allowed to cool, extracted twice with 10% hydrogen chloride, the toluene phase is dried over sodium sulfate, clarified with bone coal, filtered, washed on the filter with toluene and evaporated. The residual orange-red oil gets crystalline upon trituration with hexane. The substance is stirred in hexane, filtered and washed with hexane. The product is used for the catalytic hydrogenation without recrystallization. Yield: 18.59 g of yellow crystal (61%). M.p.: 201-202 C. (ethyl acetate). IR (KBr): 1716 (C=O), 791 cm-1. 1H-NMR (CDCl3, TMS, 400 MHz): 2.44 (3H, s), 6.41 (1H, d, J=7.9 Hz), 6.95 (1H, t, J=7.7 Hz), 7.18 (1H, t, J=7.7 Hz), 7.30 (2H, d, J=8.0 Hz), 7.37 (1H, t, J=7.7 Hz), 7.51 (1H, d, J=7.9 Hz), 7.64 (2H, d, J=8.0 Hz), 7.81 (1H, d, J=7.7 Hz), 7.96 (1H, s) ppm. 13C-NMR (CDCl3, TMS, 101 MHz): 21.6, 109.2, 121.4, 122.4, 123.0, 125.5, 128.9, 129.3, 129.5, 129.6, 130.5, 130.6, 131.8, 135.7, 138.8, 140.2, 142.1, 167.2 ppm. Analysis for the Formula C22H15Cl2NO (380.28): Calculated: C, 69.49; H, 3.98; Cl, 18.65; N, 3.68%. Found: C, 69.53; H, 4.03; Cl, 18.49; N, 3.67%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 15362-40-0.

Electric Literature of 169037-23-4,Some common heterocyclic compound, 169037-23-4, name is 5-(Trifluoromethoxy)indoline-2,3-dione, molecular formula is C9H4F3NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A lL, four-necked, jacketed flask equipped with a thermocouple, nitrogen inlet/bubbler, condenser and a mechanical stirrer was charged with 50.0 g of 5-trifluoromethoxyisatin (4) (commercially available from, for example, Aldrich), and 25 g of Amberlite FPC22H resin. The resin was distilled over toluene (200ml/100g) three times and dried at 40 0C under vacuum overnight. A quantity of 43 ml of HC(OEt)3 and 400 ml of absolute ethanol was used. The reaction mixture was heated to reflux. The batch temperature was 76.5 0C and the jacket was set at 90 0C. The mixture was held at reflux and a quantity of 21.5 ml OfHC(OEt)3 was charged at 90 minute, 180 minute, and 300 minute intervals. The mixture was held for another 2 hrs and the batch was cooled to 20 0C and filtered through a celite bed. The solution was collected and distilled to dryness under vacuum. The crude residue was re-slurried in 80 ml of 1 : 10 EtO Ac/heptane and stirred at 0 0C for an hour and filtered to collect the product. Intermediate (7) was obtained in 80% yield and >99% HPLC purity.

The synthetic route of 169037-23-4 has been constantly updated, and we look forward to future research findings.