Application of 667463-64-1,Some common heterocyclic compound, 667463-64-1, name is 6-Bromo-1-methylindoline-2,3-dione, molecular formula is C9H6BrNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-3. I (JS.O g, 63 nunol) and hydrazine hydrate (30 mL, 618 nunol) are heated to 12S C for 72 h.To the cool reaction mixtw-e DCM is added and extracted with water and 1 M HCI. The organiclayer is dried over MgS04 and concentrated. The crystaJlized residue is dissolved in DCM,methanol is added and the DCM is removed in vacuo. The crystallized product is filtered by sunction and washed with cold methanol. Yield 63%, mz 226/228 [M+H]+, rt J.l6 min, LC-MSMethod VOOJ 003.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Bromo-1-methylindoline-2,3-dione, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GRAUERT, Matthias; ANDERSKEWITZ, Ralf; GRUNDL, Marc; OOST, Thorsten; PAUTSCH, Alexander; PETERS, Stefan; WO2014/140081; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem