Adding a certain compound to certain chemical reactions, such as: 4403-36-5, name is 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4403-36-5, Computed Properties of C10H8ClNO4S
Example 42 N-({(2R,3S)-3-[(4-azepan-1-ylpyrimidin-2-yl)amino]-1-cyclohexylpyrrolidin-2-yl }methyl)-2-(1,3 -dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanesulfonamide (compound 42) N-[(2R,3S)-2-(aminomethyl)-1-cyclohexylpyrrolidin-3-yl]-4-azepan-1-ylpyrimidine-2-amine (33.2 mg) was dissolved in anhydrous tetrahydrofuran (0.8 mL) and dimethylformamide (0.4 mL) under an argon atmosphere at room temperature, trietylamine (24.8 muL) and 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanesulfonyl chloride (48.8 mg) were added into the solution and the solution was stirred at room temperature for overnight. The reaction solution was added aqueous saturated sodium hydrogen carbonate solution and extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous sodium sulfate and then concentrated. The residue was purified by Flash tube (trade mark) to obtain sulfonamide compound (49.0 mg). TLC: Rf 0.67 (chloroform: methanol = 5:1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1,3-Dioxoisoindolin-2-yl)ethanesulfonylchloride, and friends who are interested can also refer to it.
Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1852432; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem