In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7223-50-9 as follows. Recommanded Product: N-Propargylphthalimide
AgNO3 (36.1 mg, 0.21 mmol) and N-bromosuccinimide (576 mg, 3.24mmol) were added to a solution of 2-(prop-2-yn-1-yl)isoindoline-1,3-dione (2a; 371 mg, 2.00 mmol) in acetone (2.0 mL). The reactionmixture was stirred at r.t. for 16 h. Afterwards, the mixture waspoured on ice and extracted with EtOAc. The combined organic layerswere dried (anhyd Na2SO4), concentrated, and the crude product waspurified by flash chromatography (silica gel, PE/EtOAc 8:2). Bromoalkyne3a was isolated as a white solid; yield: 495 mg (1.87 mmol,94%); mp 119-120 C; Rf = 0.35 (PE/EtOAc 7:3).
According to the analysis of related databases, 7223-50-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kohr, Michael; Kazmaier, Uli; Synthesis; vol. 50; 23; (2018); p. 4690 – 4694;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem