Electric Literature of 181140-34-1,Some common heterocyclic compound, 181140-34-1, name is (R)-(-)-N-(2,3-Epoxypropyl)phthalimide, molecular formula is C11H9NO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 22.6 g (111.21 mmol) of S – (+) – N- (2,3-ethoxypropyl) phthalimide (SM1)5.34 g (27.80 mmol) of 4- (4-aminophenyl) morpholin-3-one (SM2) was added to 250 ml of a three-necked flask, followed by addition of 110 ml of absolute ethanol and the reaction was refluxed for 24 h.With tap water to 50 ~ 55 C , filter, remove the insoluble matter, collecting the filtrate, continue to cool to 10 ~ 15 C crystallization, filtration, a yellow solid. The yellow solid was dissolved in 80 ml of absolute ethanol and cooled to 5 to 10 The filter cake was dried at 50 to 60 C for 5 hours under reduced pressure. The product was obtained in a yield of 60.0% and a purity of 96.2%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (R)-(-)-N-(2,3-Epoxypropyl)phthalimide, its application will become more common.
Reference:
Patent; Chongqing Zhien Pharmaceutical Co., Ltd.; Deng Xianglin; Li Daming; Huang Chaoming; Huang Minghui; Feng Yongmei; Wang Fei; Liao Xingting; (29 pag.)CN106432218; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem