Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , HPLC of Formula: C8H4BrNO2, 87-48-9, Name is 5-Bromoindoline-2,3-dione, molecular formula is C8H4BrNO2, belongs to indolines-derivatives compound. In a document, author is Kumari, Sabita, introduce the new discover.
Design, Synthesis, and Evaluation of Anticancer Activity of Some New Spiro Indoline-2-one Derivatives
The indoline-2-one derivatives (SSSK 16-20) were designed by docking, in silico absorption, distribution, metabolism, and excretion (ADME) and predicted toxicity studies. These designed compounds were then synthesized by a three-component coupling reaction. These compounds were characterized by ‘H nuclear magnetic resonance (H-1 NMR), C-13 NMR, Fourier transform infrared, and mass spectral data. Then, all synthesized compounds were tested for anticancer activity on MDA-MB-231 and MCF-7 cell lines. The compounds having halogen at isatin ring displayed good binding scores. In silico, ADME and toxicity studies were also found significant for most of the compounds. Three compounds SSSK16, SSSK17, and SSSK19 showed significant anticancer potential against MCF-7 with GI(50) value of 0.44, 0.04, and 21.6 molar.
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