Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 59-48-3, Name is Indolin-2-one, molecular formula is , belongs to indolines-derivatives compound. In a document, author is Filatov, Vadim, Computed Properties of C8H7NO.
Synthesis of 1,3-diaryl-spiro[azetidine-2,3 ‘-indoline]-2 ‘,4-diones via the Staudinger reaction: cis- or trans-diastereoselectivity with different addition modes
A new synthetic approach for realizing biologically relevant bis-aryl spiro[azetidine-2,3 ‘-indoline]-2 ‘,4-diones was developed based on Staudinger ketene-imine cycloaddition through the one-pot reaction of substituted acetic acids and Schiff bases in the presence of oxalyl chloride and an organic base. A series of [azetidine-2,3 ‘-indoline]-2 ‘,4-diones were synthesized using this method. For comparison, the same compounds were obtained using a known technique, where ketene is generated from pre-synthesized acyl chloride. It was shown that the use of oxalyl chloride for ketene generation in the one-pot reaction at room temperature allows for the reversal of the diastereoselectivity of spiro-lactam formation, unlike previously described procedures.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 59-48-3, in my other articles. Computed Properties of C8H7NO.