Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.87-48-9, Name is 5-Bromoindoline-2,3-dione, SMILES is O=C1NC2=C(C=C(Br)C=C2)C1=O, belongs to indolines-derivatives compound. In a document, author is Romo, Pablo, introduce the new discover, Safety of 5-Bromoindoline-2,3-dione.
Regio- and stereospecific assembly of dispiro[indoline-3,3 ‘-pyrrolizine-1 ‘,5 ”-thiazolidines] from simple precursors using a one-pot procedure: synthesis, spectroscopic and structural characterization, and a proposed mechanism of formation
The synthesis and characterization of three new dispiro[indoline-3,3′-pyrrolizine-1′,5 ”-thiazolidine] compounds are reported, together with the crystal structures of two of them. (3RS,1’SR,2’SR,7a’SR)-2′-(4-Chlorophenyl)-1-hexyl-2 ”-sulfanylidene-5′,6′,7′,7a’-tetrahydro-2’H-dispiro[indoline-3,3′-pyrrolizine-1′,5 ”- thiazolidine]-2,4 ”-dione, C28H30ClN3O2S2, (I), (3RS,1’SR,2’SR,7a’SR)-2′-(4-chlorophenyl)-1-benzyl-5-methyl-2 ”-sulfanylidene-5′,6′,7′,7a’-tetrahydro-2’H-dispiro[in- doline-3,3′-pyrrolizine-1′,5 ”-thiazolidine]-2,400-dione, C30H26ClN3O2S2, (II), and (3RS,1’SR,2’SR,7a’SR)-2′-(4-chlorophenyl)-5-fluoro-2 ”-sulfanylidene-5′,6′,70,7a’-tetrahydro- 2’H-dispiro[indoline-3,3′-pyrrolizine-1′,5 ”-thiazolidine]-2,4 ”-dione, C22H17ClFN3O2S2, (III), were each isolated as a single regioisomer using a onepot reaction involving l-proline, a substituted isatin and (Z)-5-(4-chlorobenzylidene)-2-sulfanylidenethiazolidin-4-one [5-(4-chlorobenzylidene)rhodanine]. The compositions of (I)-(III) were established by elemental analysis, complemented by high-resolution mass spectrometry in the case of (I); their constitutions, including the definition of the regiochemistry, were established using NMR spectroscopy, and the relative configurations at the four stereogenic centres were established using single-crystal X-ray structure analysis. A possible reaction mechanism for the formation of (I)-(III) is proposed, based on the detailed stereochemistry. The molecules of (I) are linked into simple chains by a single N-H center dot center dot center dot N hydrogen bond, those of (II) are linked into a chain of rings by a combination of N-H center dot center dot center dot O and C-H center dot center dot center dot S C hydrogen bonds, and those of (III) are linked into sheets by a combination of N-H center dot center dot center dot N and N-H center dot center dot center dot S-C hydrogen bonds.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 87-48-9. Safety of 5-Bromoindoline-2,3-dione.