One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, formurla is C11H9NO3. In a document, author is Morales-Rios, Martha S., introducing its new discovery. Name: (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione.
Melatonin pharmacophoric motifs in the anancomeric spiranic oxindole-cycloalkane scaffold: Theoretical and H-1 NMR conformational analysis
N-[2′-oxospiro(cycloalkane-1,3′-indoline)methyl]acetamides (1a/b-4a/b), analogues conformationally restricted of neurohormone melatonin (MLT), were constructed through pharmacophoric ethyl-acetamido side chain incorporation into a chiral spiro-ring structure. A facile synthetic route was established to afford the epimeric spirocycloalkane pairs a/b starting from substituted spirocycloalkane nitriles through catalytic hydrogenation in acetic anhydride medium. The conformational profiles of the methylamido side chain were explored by computational methods. The main conformational features represent a balance between geometric restrictions imposed by the spiro-ring structure and the relative configuration of the corresponding stereocenters. The anancomeric structure of the spiranic oxindole-cycloalkane scaffold and the orientation of the amido side chain is discussed considering complete 750 MHz H-1 NMR data by applying an iterative full spin analysis (HiFSA), conformational analysis, and single crystal X-ray diffraction. The effect of the conformational restriction, ring size, and stereochemistry on melatoninergic agonist activity was analyzed in terms of pharmacophore-based virtual screening. (C) 2019 Elsevier B.V. All rights reserved.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 161596-47-0 help many people in the next few years. Name: (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione.