Let¡¯s face it, organic chemistry can seem difficult to learn, Product Details of 87-48-9, Especially from a beginner¡¯s point of view. Like 87-48-9, Name is 5-Bromoindoline-2,3-dione, molecular formula is indolines-derivatives, belongs to indolines-derivatives compound. In a document, author is Wu, Wen-Tao, introducing its new discovery.
Diastereoselective Synthesis of Spiro[indoline-3,7 ‘-pyrrolo[1,2-a]azepines] via Sequential [3+2] Cycloaddition and Ring Expansion Reaction
Spiro[indoline-3,7 ‘-pyrrolo[1,2-a]azepines] were conveniently synthesized in satisfactory yields and with high diastereoselectivity from three-component reaction of L-proline, isatins and chalcones and sequential reaction with dimethyl but-2-ynedioate or methyl propiolate in refluxing methanol. The ferrocenyl-chalcones and dibenzylideneacetones were also successfully used in this one-pot two-step reaction to give novel ferrocenyl and styryl-substituted spiro compounds. The reaction mechanism included domino [3+2] cycloadddtition reaction of azomethine ylide with chalcone and ring-expansion reaction ofin situgenerated spiro[indoline-3,3 ‘-pyrrolizine] with electron-deficient alkynes.
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