Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 446292-08-6, Name is (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@H]2CN(C3=CC=C(N4C(COCC4)=O)C=C3)C(O2)=O)C(C5=C1C=CC=C5)=O, in an article , author is Bhatt, Priyanka, once mentioned of 446292-08-6, HPLC of Formula: C22H19N3O6.
Design and Ultrasound Assisted Synthesis of Novel 1,3,4-Oxadiazole Drugs for Anti-Cancer Activity
An ultrasound assisted multi-component synthesis of a series of 2-(N-heterocycle) substituted 1,3,4-oxadiazoles have been performed. A proper IR, UV, Mass and NMR spectral analysis supported the 12 synthesized novel compounds. Compound 5-bromo-1-((4-chlorophenyl)((5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl)amino)methyl) indoline-2,3-dione (D8), displayed significant cytotoxicity against all the three human cancer cell lines studied in this article (breast cancer cell line MCF-7, colorectal cancer cell line HT-29 and liver cancer cell line Hep G2) using MTT assay. Further in silico target hunting using Chem Mapper led to the identification of two important cancer targets; EGFR and CDK2 kinases. Compound D8 was studied in detail using AutoDock and displayed high binding energies with the two proteins. Quantum chemical calculations of the designed compound D8 at the active site with specific amino acids for both the proteins showed stronger interactions at the active sites similar to the docking studies.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 446292-08-6, you can contact me at any time and look forward to more communication. HPLC of Formula: C22H19N3O6.