Chemistry is an experimental science, SDS of cas: 59-48-3, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 59-48-3, Name is Indolin-2-one, molecular formula is C8H7NO, belongs to indolines-derivatives compound. In a document, author is Pan, Liu-Na.
Diastereoselective synthesis of dispiro[indoline-3,3 ‘-furan-2 ‘,3 ”-pyrrolidine]via[3+2]cycloaddition reaction of MBH maleimides of isatins and 1,3-dicarbonyl compounds
In the presence of mixed bases DABCO and K2CO3, the reaction of MBH maleimides of isatins with various cyclic 1,3-dicarbonyl compounds such as 1,3-cyclohexanedione, dimedone, 4-hydroxychromenone and benzoylacetonitrile afforded functionalized dispiro[indoline-3,3 ‘-furan-2 ‘,3 ”-pyrrolidines] in satisfactory yields and with high diastereoselectivity. This formal [3 + 2]cycloaddition proceeded with nucleophilic substitution of an allylammonium ylide and oxa-Michael addition of an enolate. However, a similar reaction of MBH adducts of isatins derived from acrylonitrile and methyl acrylate resulted in functionalized spiro[indoline-3,4 ‘-pyranes] in good yields through formal [3 + 3]cycloaddition reaction.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 59-48-3, in my other articles. SDS of cas: 59-48-3.