Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C8H6BrNO, 99365-40-9, Name is 6-Bromoindolin-2-one, molecular formula is C8H6BrNO, belongs to indolines-derivatives compound. In a document, author is Jha, Anand Mohan, introduce the new discover.
Oligosaccharides as Green Catalyst for One-Pot Multicomponent Synthesis of Spirooxindole Derivatives in Water
A one pot synthetic methodology has been developed towards multicomponent synthesis of spiro[indoline-3,2′-quinazoline]-2,4′(3’H)-dione from isatoic anhydride, isatin and primary amines in aqueous medium via supramolecular catalysis. An untapped potential of beta-Cyclodextrin to mediate multicomponent reactions in aqueous medium has been revealed. Developed protocol was further verified by extrapolating the synthetic protocol using different isatin derivatives and amine analogues. In other synthetic scheme, some compounds were synthesized by reaction of various substituted benzaldehydes, Isatoic anhydride and primary amines. Synthesized library of compounds were further characterized using various spectroscopic techniques. During all the synthetic process, the catalytic efficiency of cyclodextrin was exploited. Efficiency of all the three forms of cyclodextrins were tested to find the best reaction for synthesis of spiro compounds. The usefulness of beta-cyclodextrin was proved by showing its reusability. The essential role of beta-cyclodextrin in the synthetic methodology is further proved by doing the control experiments which showed that no product was formed in the absence of catalyst. The attachment of reactant molecule was also proved by doing 1H NMR of reaction mixture at different time interval in D2O. On the basis of observation, a plausible mechanistic pathway of reaction was proposed. Other two forms of cyclodextrins were also eliminated on the ground of their insuitability in the formation of desired product. Catalyst reusability was studied and it was shown that our catalytic system is useful without any significant loss in catalytic potential even after 5 cycles. Catalyst recovery procedure was established and was used without any significant loss of catalytic activity upto 5 times.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 99365-40-9. Formula: C8H6BrNO.