Chemistry, like all the natural sciences, SDS of cas: 161596-47-0, begins with the direct observation of nature¡ª in this case, of matter.161596-47-0, Name is (S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione, SMILES is O=C1N(C[C@@H]2OC2)C(C3=C1C=CC=C3)=O, belongs to indolines-derivatives compound. In a document, author is Karaman, Muhammet, introduce the new discover.
Inhibition effect of rhodanines containing benzene moieties on pentose phosphate pathway enzymes and molecular docking
Recently, inhibition studies of pentose phosphate pathway (PPP) enzymes have come out as an encouraging approach for pharmacological intervention in a variety of disorders. For this purpose, the rhodanines (Ph-Rhs) containing different benzene moiety were obtained via a green synthetic approach over a one pot reaction. We tested their inhibition effect on PPP enzymes glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD). As a result of these studies, inhibition constant (K-i) of Ph-Rhs on PPP enzymes were found in the range of 6.57 +/- 2.03 to 91.60 +/- 9.25 mu M for G6PD and 11.17 +/- 3.01 to 64.51 +/- 4.26 mu M for 6PGD. Moreover, binding energies were calculated with docking studies as -5.234 and -5.071 kcal/mol for G6PD and 6PGD, respectively. (C) 2020 Published by Elsevier B.V.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 161596-47-0. SDS of cas: 161596-47-0.