Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 87-48-9, Name is 5-Bromoindoline-2,3-dione. In a document, author is Meng, Tingting, introducing its new discovery. Category: indolines-derivatives.
Recent advances in indole dimers and hybrids with antibacterial activity against methicillin-resistantStaphylococcus aureus
Methicillin-resistantStaphylococcus aureus(MRSA), one of the major and most dangerous pathogens in humans, is a causative agent of severe pandemic of mainly skin and soft tissue and occasionally fatal infections. Therefore, it is imperative to develop potent and novel anti-MRSA agents. Indole derivatives could act against diverse enzymes and receptors in bacteria, occupying a salient place in the development of novel antibacterial agents. Dimerization and hybridization are common strategies to discover new drugs, and a number of indole dimers and hybrids possess potential antibacterial activity against a panel of clinically important pathogens including MRSA. Accordingly, indole dimers and hybrids are privileged scaffolds for the discovery of novel anti-MRSA agents. This review outlines the recent development of indole dimers and hybrids with a potential activity against MRSA, covering articles published between 2010 and 2020. The structure-activity relationship and the mechanism of action are also discussed to facilitate further rational design of more effective candidates.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 87-48-9 help many people in the next few years. Category: indolines-derivatives.