The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 550-44-7, Name is 2-Methylisoindoline-1,3-dione, SMILES is CN1C(=O)C2=C(C=CC=C2)C1=O, in an article , author is Lobe, Maloba M. M., once mentioned of 550-44-7, Name: 2-Methylisoindoline-1,3-dione.
3 ‘,4 ‘-Dihydro-2 ‘ H-spiro[indoline-3,1 ‘-isoquinolin]-2-ones as potential anti-cancer agents: synthesis and preliminary screening
Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of biological activities including anti-cancer activity, and are therefore recognized as two privileged scaffolds in drug discovery. In the present study, 24 3 ‘,4 ‘-dihydro-2 ‘ H-spiro[indoline-3,1 ‘-isoquinolin]-2-ones, designed as molecular hybrids of THIQ and OX, were synthesized and screened in vitro against 59 cell lines in the NCI-60 screen. Twenty compounds displayed weak to moderate inhibition of cell proliferation; among them, three compounds displayed at least 50% inhibition of cell proliferation. The compounds appeared to target primarily renal cell cancer lines; however, leukaemia, melanoma, non-small cell lung cancer, prostate, ovarian and even breast cancer cell lines were also affected. Therefore, this class of spirooxindoles may provide useful leads in the search for new anti-cancer agents.
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