Synthetic Route of 50727-04-3, A common heterocyclic compound, 50727-04-3, name is 5-Methoxyisoindoline-1,3-dione, molecular formula is C9H7NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-bromo-5-trifluoromethylpyridine (224 mg, 1 mmol), triethylene diamine (224 mg, 2 mmol),4-methoxyphthalimide (354 mg, 2 mmol), potassium phosphate (434 mg, 2 mmol),N, N-dimethylacetamide (2 ml) was added to the dry reaction tube and suspended in an oil bath at 120 C for 24 h.After cooling the reaction system, 15 ml of water was added and the aqueous phase was extracted three times with 30 ml of ethyl acetate,The organic phases were combined and the solvent was evaporated under reduced pressure to give 338 mg of a colorless solid, 5-methoxy-2- (2-(4- (5-trifluoromethylpyridyl) 2-piperazinyl) 1-ethyl) isoindole-1,3-dione in a yield of 78%.
The synthetic route of 50727-04-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yichun University; Zhu Qiming; Chen Mingwei; (20 pag.)CN106317021; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem