In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 84575-27-9, name is 7-Methoxyindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C9H7NO3
To 7-methoxy-1 H-indole-2,3-dione (SM-1 b) (500 mg; 2.82 mmol) in DMF (5.0 mL) is added K2C03 (585 mg; 4.23 mmol) in one portion. The reaction mixture is stirred at rt for 30 min before iodomethane (SM-5b) (0.230 mL; 3.67 mmol) is added and stirring is continued at rt for 2 h. The reaction mixture is poured into water, acidified with 4 N HCIaq. and stirred for 30 min. The resulting precipitate is collected by filtration, washed with water and dried in vacuo to give 7-methoxy-1 -methyl-2,3-dihydro-1 H-indole-2,3-dione (A-2a) (HPLC-MS: tRet. = 0.87 min; MS (M+H)+ = 192; method 1 ).
The synthetic route of 84575-27-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; STEURER, Steffen; DAHMANN, Georg; KERRES, Nina; KOEGL, Manfred; (210 pag.)WO2018/108704; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem