Synthetic Route of 16800-68-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16800-68-3 as follows.
3 – (4 – Methoxyphenyl) propyne acid 4 – nitrophenyl-unitz (89.2 mg 0.3 mmol), was obtained. N- Acetylindole -3 -unitz 26.3 mg (0.15 mmol), such as carbene-like (0.015 mmol) 3.96 mg, 1, 8 – diazabicycloundecene -7 – (0.3 mmol 45 mul) and methylene methylene chloride as shown in Formula IV, were 3 ml placed 25 ml in a unitunito-two-port bottle under 30 C inert atmosphere protection, unitunitunitaceous conditions 3h, and mixtures thereof. The reaction solution was concentrated, and eluted, eluting with a mixed 10:1 solvent of petroleum ether: ethyl acetate ratio timetime as eluent column chromatography to collect all the detected eluate fractions, and the solvent was evaporated 27 mg and the solvent was evaporated to obtain the unitz , 55% and beiunit_.
According to the analysis of related databases, 16800-68-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; China Pharmaceutical University; Du Ding; Sun Kewen; (10 pag.)CN110156800; (2019); A;,
Indoline – Wikipedia,
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