Synthetic Route of 58083-59-3, The chemical industry reduces the impact on the environment during synthesis 58083-59-3, name is 6-Chloroisoindolin-1-one, I believe this compound will play a more active role in future production and life.
A mixture of 6-chloro-2, 3-dihydro-isoindol-1-one (0.115 g, 0.68 [MMOL)] and 6M hydrochloric acid (8 ml) in dioxan (1 ml) was heated to [110¡ãC] for 18 hours. After cooling to room temperature the solid was filtered off and dried in vacuo to give the title compound (0.0055g, 4 percent) as a beige solid. 1H-NMR (400 MHz, DMSO): [A] = 4.30 (brs, 2H), 7.58 (dd, 1H), 7.76 (dd, 1H), 8.22 (brs, 3H). LRMS [(ELECTROSPRAY)] : m/z [MH+] 186. Microanalysis : Found: C, 43.13 ; H, 4.05 ; N, 6. 18. [C8H8N02CI.] HCI requires C, 43.26 ; H, 4.08 ; N, 6. [31percent.]
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Chloroisoindolin-1-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/14357; (2004); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem