2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C9H6BrNO2
General procedure: A 5 mL of two-necked flask with 25 mg of freshly activated 4A molecular sieves and micro stirbar was flame heated under vacuum and refilled with Nitrogen. Isatin derivative (0.10 mmol, in 0.5 mL of benzene, 0.5 M) was charged to the cooled round bottom under argon, followed by addition of carbamoylsilane (0.15 mmol) in 0.1 mL of benzene. The sealed reaction mixture was stirred at 60 C until no isatin derivatives could be detected by TLC. Volatiles were removed in vacuum to afford the crude product which was purified by column chromatography on silica gel (petroleum ether/ethyl acetate combination) to give compound 3.6
The synthetic route of 2058-72-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liang, Jin-Yan; Wang, Hui; Yang, Yan-Li; Shen, Shou-Jie; Chen, Jian-Xin; Tetrahedron Letters; vol. 58; 27; (2017); p. 2636 – 2639;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem