Reference of 181140-34-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 181140-34-1 name is (R)-(-)-N-(2,3-Epoxypropyl)phthalimide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a reaction vessel were added (R)-glycidylphthalimide 5.80 g (28.6 mmol), 4-chloro-2-methoxyphenol 3.17 g (20.0 mmol), potassium carbonate 2.76 g (20 mmol) and DMF 60 mL, and the mixture was stirred at 80 C. for 46 hours. After evaporation of the solvent, to the condensed residue was added 1,2-dichloroethane and the mixture was washed with an aqueous 3% NaOH solution, an aqueous 1% HCl solution and an aqueous 5% NaCl solution successively. The organic layer was taken, and the solvent was evaporated to give (R)-1-(4-chloro-2-methoxyphenoxy)-3-phthalimido-2-propanol 4.20 g (yield 59%, chemical purity 90%) as a pale yellow solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (R)-(-)-N-(2,3-Epoxypropyl)phthalimide, and friends who are interested can also refer to it.
Reference:
Patent; Miki, Yasushi; Mikami, Masafumi; US2006/19993; (2006); A1;,
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