Related Products of 101207-45-8, These common heterocyclic compound, 101207-45-8, name is 2-(4-Methylbenzyl)isoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 243 2-(4-methylbenzyl)isoindoline-1,3-dione (1 g, 3.8 mmol) and 24 hydrazine hydrate (752 mg, 15 mmol, 730 muL) in 113 MeOH (10 mL) was stirred at 20 C. for 3 hours. The mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (dichloromethane:methanol (with 5% 245 ammonia in 55 water)=0:1 to 5:1) to give 246 p-tolylmethanamine (160 mg).
Statistics shows that 2-(4-Methylbenzyl)isoindoline-1,3-dione is playing an increasingly important role. we look forward to future research findings about 101207-45-8.
Reference:
Patent; H. Lundbeck A/S; Juhl, Karsten; Jessing, Mikkel; Langgard, Morten; Vital, Paulo Jorge Vieira; Kehler, Jan; Rasmussen, Lars Kyhn; Clementson, Carl Martin Sebastian; Marigo, Mauro; (154 pag.)US2019/194189; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem