Application of 59-48-3, These common heterocyclic compound, 59-48-3, name is Indolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation of 5-Bromo-2-indolinone 2-indolinone (1.3 g) in 20 mL of acetonitrile was collected to -10 C. and 2.0 g of N-bromosuccinimide was slowly added with stirring. The reaction was stirred for 1 hour at 10 C. and 2 hours at 0. The precipitate was collected, washed with water and dried to give 1.9 g (90% yield) of the title compound.
The synthetic route of 59-48-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sugen, Inc.; US6316635; (2001); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem