In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20780-72-7, name is 4-Bromoisatin belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H4BrNO2
General procedure: Isatin 1 (1 mmol), active methylene 2 (1 mmol), phosphite 3 (1mmol), and [DABCO-H][AcO] (17.2 mg, 0.1 mmol) were added to THF(0.3 mL). Then the reaction mixture was vigorously stirred at r.t. Theprogress of the reaction was monitored by TLC (n-hexane?EtOAc,4:1). After completion of the reaction, cold H2O (2 mL) was added. TheIL catalyst dissolved in the H2O and the insoluble crude products wereisolated by simple filtration. The crude products were recrystallizedfrom EtOH to afford pure final products. After removal of the H2O underreduced pressure, the catalyst [DABCO-H][AcO] could be directlyreused for the next run under similar reaction conditions.
The synthetic route of 20780-72-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Song, Lan-Lan; Yang, Cheng; Yu, Ya-Qin; Xu, Da-Zhen; Synthesis; vol. 49; 7; (2017); p. 1641 – 1647;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem