In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 341988-36-1 as follows. name: Methyl indoline-6-carboxylate
Dihydroindole-6-carboxylic acid methyl ester (3.60 g, 0.02 mol) was dissolved in a 100 mL single-mouth bottle containing 50 mL of ethanol:water (4:1), and 10 mL (2M aqueous potassium hydroxide solution) was added at 45 ¡ã C. The reaction was carried out for 2 hours. After the reaction was completed, the reaction mixture was neutralized with a 2M aqueous hydrochloric acid solution to pH=6, and then extracted with dichloromethane (150 mL¡Á3).The combined organic phases were dried and concentrated to give the title compound.
According to the analysis of related databases, 341988-36-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Wang Yong; Zhao Liwen; Ge Chongxun; Huang Yiqiang; Cao Chen; Li Qingqing; Hou Shaohua; (63 pag.)CN108276382; (2018); A;,
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