The synthetic route of 3-(1,3-Dioxoisoindolin-2-yl)propanal has been constantly updated, and we look forward to future research findings.
Related Products of 2436-29-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
< 1 - 12> 2- { 3-[4-(4-bromo-2-fluoro-pheny lamino)-7-( 1 -methyl-piperidin-4- ylmethoxy)-quinazolin-6-ylamino]-propyl}-isoindol-l,3-dione; The compound of (2.0 g, 0.0043 mol) was dissolved in 40 ml of ethanol, the compound of <1-11> (1.3 g, 0.0064 mol) and sodium cyanoborohydride (500 mg, 0.0086 mol) were added thereto, and stirred at room temperature for 6 hours after adding a catalytic amount (1 m-C) of acetic acid thereto. When the reaction was terminated, the reacted solution was distilled under a reduced pressure, and saturated sodium bicarbonate solution was added thereto. The resulting solution was extracted with dichloromethane, dried over magnesium sulfate, and distilled under a reduced pressure. The resulting residue was subjected to column chromatography to obtain the title compound 1.3 g (yield: 46%). 1H NMR (CDCl3) delta: 8.56 (s, IH), 8.41 (t, IH), 7.81-7.68 (m, 4H), 7.34-7.30 (m, 2H), 7.06 (s, IH), 6.63 (s, IH), 5.03 (br, NH), 4.00 (d, 2H), 3.85 (t, 2H), 3.36 (d, 2H), 2.96 (d, 2H), 2.3 (s, 3H), 2.14-2.02 (m, 3H), 2.00-1.88 (m, 2H), 1.59-1.53 (m, 2H).
The synthetic route of 3-(1,3-Dioxoisoindolin-2-yl)propanal has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HANMI PHARM. CO., LTD.; WO2007/55513; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem