Synthetic Route of 1504-06-9, These common heterocyclic compound, 1504-06-9, name is 3-Methyloxindole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a 10 mL Schlenk flask was added 3-methyl 2-indolone (0.2 mmol),Tert-butyl nitrite (t-BuONO, 0.4 mmol) and 1,4-dioxane (2 mL). The reactor was then stirred at 25 C. The reaction progress was monitored by TLC or GC until the reaction mass 3-methyl-2-indolone reaction is complete, The reaction was quenched with saturated brine and the organic phase was recovered. The aqueous phase was extracted with ethyl acetate and the organic phases were combined. The organic phase was dried over anhydrous sodium sulphate, filtered and evaporated under reduced pressure.The residue was subjected to column chromatography (n-hexane / ethyl acetate) to give the target product 3-nitro-2-indolinone derivative I-2 in a yield of 71%
The synthetic route of 1504-06-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ningbo University; Wu Yi; Wei Wenting; Zhu Wenming; Huang Yiling; Wu Kewei; Cao Yiqi; Wang Yining; Zhu Liwei; (7 pag.)CN107200705; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem