Synthetic Route of 20870-79-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20870-79-5 name is 5-Nitroindolin-2-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a mixture of 5-nitroindolin-2-one (Int 5a) (3.00 g, 16.8 mmol) in 1 ,2-dichloroethane (60 mL) was added phosphorus(V) oxybromide (4.59 g, 16.0 mmol). The mixture was heated to 90 C for 0.5 h. The mixture was cooled to just below reflux temperature. Imidazole (1.26 g, 18.5 mmol) was added and the mixture was heated to 90 C for 2 h. The mixture was cooled to rt and diluted with ice-water and sodium bicarbonate (solid). The mixture was extracted with DCM (4 x 100 ml_). The combined organic layers were washed with brine, dried over anhydrous Na2S04, filtered and concentrated to dryness. The residue was purified by silica gel column chromatography (gradient PE to PE/EtOAc = 3:1 ) to afford the title compound as a yellow solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Nitroindolin-2-one, and friends who are interested can also refer to it.
Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; PINTO, Sheena; ANDERHUB, Simon; GEGE, Christian; DEUSCHLE, Ulrich; HOFFMANN, Thomas; (122 pag.)WO2020/21024; (2020); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem