Synthetic Route of 61-70-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61-70-1 as follows.
To a round-bottom flask containing a solution of N-methyl-2-oxindole (4.85 g, 33 mmol) in acetic anhydride (36 mL, 381 mmol), DMAP (118 mg, 0.96 mmol) was added. The mixture was heated at 140 C for 5 h. The mixture was evaporated under reduced pressure, the crude residue was dissolved in MeOH (80 mL) and a solution of KOH (18 g, 321 mmol) in MeOH (120 mL) at 0 C was added. The solution was stirred at r.t. for 22 h then cooled in an ice-bath at 0 C and 12 M aqueous HCl was added until pH 3. At this point, H2O (140 mL) was added and the solution was extracted with EtOAc (3 140 mL). The organic phases were dried over MgSO4, filtered, and concentrated. The residue was purified by flash chromatography (hexane/EtOAc) to give pure 2a. Yield: 5.5 g (88%); purple solid; mp 109-110 C (hexane/EtOAc) (Lit. 12 110-111 C).
According to the analysis of related databases, 61-70-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ortega-Martinez, Aitor; Molina, Cynthia; Moreno-Cabrerizo, Cristina; Sansano, Jose M.; Najera, Carmen; Synthesis; vol. 49; 23; (2017); p. 5203 – 5210;,
Indoline – Wikipedia,
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