Reference of 39755-95-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39755-95-8 as follows.
Synthesis Example 90; ()-trans-6-Benzyl-3-hydroxy-2, 2-dimethyl-4-[(2-phenylethyl) amino] -2,3, 4,6-tetrahydro -pyrano [2, 3-findol-7-one ;N-Benzyl-5-methoxyisatin To a solution of 5-methoxyisatin (15.0 g, 84.7 mmol) in DMF (100 mL), sodium hydride (5.1 g, 127 mmol) and benzyl bromide (12.1 mL, 101.6 mmol) were added at 0C, and the resulting mixture was stirred for 1 hour. Water was added thereto, and the resulting solution was extracted with ethyl acetate. The resulting organic phase was washed with saturated aqueous ammonium chloride solution and then with saturated sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated to obtain the aimed product (yield : 96%). Brown solid 1 H-NMR (CDC13) 6 ; 3.77 (s, 3H), 4.91 (s, 2H), 6.67 (d, J= 8.5 Hz, 1H), 7.0-7. 1 (m, 1H), 7.15 (m, 1H), 7.25-7. 45 (m, 5H)
According to the analysis of related databases, 39755-95-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LTD.; WO2005/90357; (2005); A1;,
Indoline – Wikipedia,
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